Depth Filters Handle Single-Stage Clarification of Pretreated Feed Streams

Sept. 19, 2013
Filters eliminate the need for centrifugation.

EMD Millipore, the life science division of Merck KGaA of Darmstadt, Germany, introduced the Clarisolve depth filter for single-stage clarification of pretreated feed streams. The Clarisolve depth filter is a clarification device with a gradient density structure specifically designed to the particle size distributions of pretreated feed streams.

Clarisolve depth filters process pretreated feeds in a reduced footprint without the need for the secondary stage of clarification. The use of Clarisolve depth filters eliminates the need for centrifugation, which enables implementation of a fully single-use process train and also reduces the pre-use flushing requirements. This technology was developed to address the shortcomings of traditional downstream clarification approaches when processing high cell density and high-product titer cell cultures.

EMD Millipore has also developed a cationic pDADMAC (poly diallyldimenthyl ammonium chloride) flocculation reagent targeted for biopharmaceutical applications which can be used as a pretreatment in combination with the Clarisolve depth filters. pDADMAC treatment, in combination with Clarisolve depth filters, provide a solution for harvesting high cell density cultures and can be incorporated into current clarification platforms.

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