The team used Fe3O4 nanoparticles to produce a diverse range of propargylamines at moderate to high yields. These compounds can serve as building blocks and skeletons of biologically active compounds, the researchers note.
The Fe3O4 nanoparticles were magnetically separated (Figure 1), washed with ethyl acetate, air dried and then used again without further purification. The materials went through 12 such cycles without significant loss of catalytic activity, say the researchers.
Work is underway on using the nanoparticles for other reactions, notes Chao-Jun Li of McGill's Department of Chemistry.