Process Filtration Scale-Up from Lab to Commercial Operation

June 2, 2015

This article discusses process filtration approach developed for each technology stage starting from batch filtration in the lab to continuous filtration for the full-scale commercial operation. Process engineers must not “jump to conclusions”, a reference from Sherlock Holmes and Dr. John Watson who prove time and again is that there is no benefit to jumping to conclusions. Therefore, laboratory / bench top filtration testing is covered for problem analysis, technology selection and pilot and demonstration scale-up. The paper continues with the filtration testing and then scale-up to the commercial size. Finally, the paper concludes with a general review of the problem-solving skills of Holmes and Watson and how these skills can be utilized by process engineers as a framework for “idea-generation” when analyzing a new process scale-up.

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This article discusses process filtration approach developed for each technology stage starting from batch filtration in the lab to continuous filtration for the full-scale commercial operation. Process engineers must not “jump to conclusions”, a reference from Sherlock Holmes and Dr. John Watson who prove time and again is that there is no benefit to jumping to conclusions. Therefore, laboratory / bench top filtration testing is covered for problem analysis, technology selection and pilot and demonstration scale-up. The paper continues with the filtration testing and then scale-up to the commercial size. Finally, the paper concludes with a general review of the problem-solving skills of Holmes and Watson and how these skills can be utilized by process engineers as a framework for “idea-generation” when analyzing a new process scale-up.

Download now.