This article discusses the choice of thin-cake (2 25 mm) separation technologies and their benefits to optimizing the effectiveness of the production process. The paper continues with a
discussion of clean-in-place operations to meet current Good Manufacturing Practices (cGMP) guidelines including riboflavin test and validations.
Manufacturing a pure product can be critically important to the next steps in the manufacture of a powder-based product. As a result the removal of residual moisture and solvents from the crystallization, filtration and drying steps can be crucial to producing a stable product.
This application note from Delta Controls outlines selection and installation criteria for using admittance probes to monitor the level of powders, liquids and other materials. Dielectric constants of more than 200 materials are included.
Dow Chemical maintains thousands of batch control systems world-wide built on its proprietary MOD 5 computer system. Over decades, they have been meticulous to preserve and enhance these systems. Dow intends to preserve and reap the rewards of this diligence by developing reverse engineering best practices and tools to migrate this intellectual property to next-generation platforms.
EPA tracks emissions of six principal air pollutants - carbon monoxide, lead, nitrogen oxides, particulate matter, sulfur dioxide, and volatile organic compounds. All have decreased significantly since passage of the Clean Air Act in 1970 - except for nitrogen oxides.
In this article, Kumar Dhanasekharan, Ph.D., technical specialist with the computational fluid dynamics (CFD) specialist Fluent, Inc., shows how modelling crystallizers using CFD can help improve process understanding, control crystal size distribution (CSD) and improve pharmaceutical crystallization results.
Batch process control security is becoming a critical concern for the process control domain, IT technology infrastructure and the business enterprise. This paper explores several key security concerns in batch control system architectures and methods for addressing these issues.
Batch manufacturing systems must maintain the status of equipment, including which are available, dirty, out of service, etc. In industries that enforce Good Manufacturing Practices (GMPs), additional status types and values for process equipment must be maintained. Rules associated with the equipment status can be complex and involve the equipment class, current equipment state and time in the current
state. This paper covers the operator interface used to review the equipment status and the interlocking requirements between the recipe and batch phases based on multiple status types.
This document describes best practices for the reference architecture for a process control system network and its interfaces to a corporate network. The papers objective is to give the reader an understanding of the techniques utilized to securely connect these networks.
Maintaining a competitive edge is becoming more difficult as energy costs continue to rise. By investing in sustainable buildings, manufacturers are improving bottom-line business performance and creating value through integrated financial, environmental and social strategies and measurements.
This application note describes two technology solutionscontinuous weight information using loadcell systems or level information using ultrasonic systemsto the problems faced by day bins supplying downstream operations.
Safety Instrumented Systems (SIS) are designed to monitor the process and control outputs to prevent or mitigate hazardous events. The design process strives for inherent safety, which is enhanced by applying multiple independent safety layers. Learn how to prevent accidents with prevention layers and minimise the consequences with mitigation layers.