Spectroscopy Offers Endless Possibilities For Process Control

By Brian Sullivan, Valin Corporation, for our sister publication Pharmaceutical Manufacturing

Feb 26, 2016

Process engineers in the pharmaceutical manufacturing industry are constantly seeking ways to achieve more precise control over the manufacturing process. With incredibly high quality control standards resulting from the important role that pharmaceuticals play in public health, extreme measures are often taken to ensure that products are of the highest quality and consistency possible. In contrast to traditional methods of costly and time-consuming sample monitoring, a new technology from Prozess Technologie provides closed-loop spectroscopy, which is able to provide real-time measurement on the manufacturing line itself without stopping the production process. When applied correctly, this technology yields much greater process control than previously possible while delivering the twin benefits of reduced cost and time associated with quality control testing.

How It Works

Commonly regarded as the world’s most precise molecular measurement technique, spectroscopy is the study of the unique interactions between matter and radiated energy. These interactions can be used to derive chemical information about a sample of material. For process measurement purposes, frequencies along the electromagnetic spectrum ranging from ultraviolet to infrared are pointed toward a sample, and the resulting reflection or absorption of the light is analyzed to extract valuable information about the sample. The data gained in this process can be used to precisely determine chemical and physical information about a sample, such as the concentration of a target compound or active pharmaceutical ingredient (API).

Read the rest of the article from our sister publication Pharmaceutical Manufacturing.

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