Definitely. Always pose such questions to your valve manufacturer. Most installation instructions focus on mechanical issues (flanges and the like), and say nothing about piping issues. When used as a control valve, straight run pipe distances upstream and downstream are advisable (Keystone: 10D to 20D upstream; 3D to 5D downstream http://www.keystonevalves.com/pdf/Keystone%20320%20322%20IOM.pdf). Also ask about any effect of upstream piping, pumps, valves, etc., on preferred stem orientation (horizontal vs. vertical).
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