In our process we are carrying out a reaction with TFA at 105-110 degrees C. Solvent used for the process is DMF. Reaction mass pH is 2. Time of reaction is 6 to 7 hours. For this process is a glass lined reactor compatible?
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Brian Dalder Forum Moderator 175 Posts
Re: Is a glass lined reactor compatible for a reaction with TFA?5 April 2012 at 1:29pmTrifluoroacetic acid is a very strong acid. I suspect a glass lined reactor would be a very good candidate for your reaction. The fact that the acid contains fluorine should not be an issue since these atoms are tightly bound to a carbon atom and won't contribute fluoride ions which are corrosive to glass. If you are running lab reactions in glassware with no visible effect you may have already generated some corrosion data!