The traditional approach to experimentation, often referred to as the scientific method, requires changing only one factor at a time (OFAT), but this method only allows one to see things one dimension at a time. By varying factors only at two levels each, but simultaneously rather than one at a time, experimenters can uncover important interactions.
Author: Mark J. Anderson and Patrick J. Whitcomb, Stat-Ease
While fermentation-based syntheses were once reserved for producing high-value specialty chemicals and biopharmaceuticals, bioprocess routes now are gaining increasing attention for commodity products.
Author: John L. Shaw, P.E., and Scott A. Rogers, P.E., CH2MHill Lockwood Greene