Evaluate SMB Chromatography for Your Separation

Here's a quick way to determine whether the technique suits your processing needs.

By Bruce Pynnonen, Shawn Feist, Yogesh Hasabnis, David Albers and Timothy Frank, The Dow Chemical Co.

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A mini-plant study helps to demonstrate the required separation, to develop an accurate process simulation and to further refine and optimize the operation to maximize productivity (the mass of desired product attained per unit volume of separation media) and minimize solvent consumption (mass or volume of solvent consumed per unit mass of product) [7]. We've successfully used this strategy to evaluate and optimize the protein separation cited earlier and to evaluate a number of proprietary applications.

Initial feasibility often can be assessed in a week or two of pulse test work; subsequent mini-plant work can be completed in one or two months, providing sufficient information to develop budgetary estimates of capital and operating costs for a large-scale installation.

BRUCE PYNNONEN is a senior applications specialist and SHAWN FEIST is a lead engineer with Dow Water and Process Solutions, Midland, Mich. YOGESH HASABNIS is a senior engineer in the Engineering & Process Sciences Laboratory at Dow's Research Center in Pune, India. DAVE ALBERS is a research scientist in Dow's Analytical Sciences Laboratory in Midland. TIMOTHY FRANK is a fellow and senior technical manager at Dow's Engineering Sciences Laboratory in Midland. Contact them via tcfrank@dow.com.


REFERENCES
1. Broughton, D.B. and C.G. Gerhold, "Continuous Sorption Process Employing Fixed Beds of Sorbent and Moving Inlets and Outlets," U.S. Patent 2,985,589 (1961).
2. Ruthven, D.M. and C.B. Ching, "Counter-current and Simulated Counter-current Adsorption Separation Processes" Chem. Eng. Sci., 44, pp. 1,011–1,038 (1989).
3. Wankat, P.C., "Separation Process Engineering," 2nd ed., pp. 649–654, Prentice Hall, Upper Saddle River, N.J. (2007).
4. Nicoud, R.M., "Simulated Moving-Bed Chromatography for Biomolecules," pp. 475–509, Chapter 13 in "Handbook of Bioseparations," S. Ahuja, ed., Academic Press, San Diego, Calif. (2000).
5. Pynnonen, B.W., "Simulated Moving Bed Processing: Escape from the High-Cost Box," J. Chromatogr. A, 827, pp. 143–160 (1998).
6. Mihlbachler, K. and O. Dapremont, "SMB Chromatography Offers Real Attractions," Chemical Processing, 68, No. 9, pp. 38–41 (Sept. 2005).
7. Feist, S.D., Hasabnis, Y., Pynnonen, B.W. and T.C. Frank, "SMB Chromatography Design Using Profile Advancement Factors, Miniplant Data, and Rate-Based Process Simulation," AIChE J., 55, No. 11, pp. 2,848–2,860 (Nov. 2009).
8. deRosset, A.J., Neuzil, R.W. and D. J. Korous, "Liquid Column Chromatography as a Predictive Tool for Continuous Countercurrent Adsorptive Separations," Ind. Eng. Chem. Proc. Des. Dev., 15, pp. 261–266 (1976).
9. Chin, C.Y. and N.-H.L. Wang, "Simulated Moving Bed Equipment Designs," Separation and Purification Rev., 33, No. 2, pp. 77–155 (2004).
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