Automated Feeding Enhances Biologics Production

On-demand nutrient addition provides improved cell health, higher product titers and consistent quality

Bill Campbell, Stratophase Ltd.
pharma mn

The majority of the new biopharmaceuticals and those in development today are produced in complex mammalian cell cultures — typically involving tens of biochemical species and hundreds of biochemical reactions. These biologics such as therapeutic proteins and monoclonal antibodies now account for more than 70% of the top-selling treatment drugs. Success in efficiently performing the complex and interdependent metabolic reactions critically depends upon the precise makeup of the cell culture medium and the nutrient feed regime, which controls the medium composition throughout the duration of the drug production process. The biopharmaceutical industry long has recognized…

Full Story

Don't Miss These Online Exclusives

The CP 50

cp50 thumbChemicalProcessing.com has selected 50 companies that play a key role in trends and developments in the chemical industry. Check out the latest news about these influential firms.

Ask the Experts

ate thumbTap the expertise of authorities on a wide variety of processing-related subjects, and read answers to hundreds of questions. Access the experts.

cartoon 150610 100 120Comical Processing Cartoon

Our pal Jerry King, award-winning artist, provides the cartoon. We want you to pen the funny captions. Submit your caption now.

Quick Poll

This month's poll: How has your site's inventory of spare parts changed in the last two years?

Most Recent

  • Automated Feeding Enhances Biologics Production

    By Bill Campbell, Stratophase Ltd.

    The majority of the new biopharmaceuticals and those in development today are produced in complex mammalian cell cultures — typically involving tens of biochemical species and hundreds of biochemical reactions. These biologics such as therapeutic proteins and monoclonal antibodies now account for…

    Full Story
  • Tiptoe Around Trouble

    By Dirk Willard, Contributing Editor

    Looking back at his project I wondered how he ever could foul it up this badly — at least unintentionally. He’d hired an offshore engineering company half-a-world away to save money. He hadn’t carefully defined the material properties, basic engineering document and drawings (BEDD) or the…

    Full Story
  • Industrial Energy Efficiency Gets Spotlight

    By Mark Rosenzweig, Editor in Chief

    In June, the U.S. Department of Energy (DOE), Washington, D.C., sent Congress a report that highlights various issues that keep industry from achieving better energy efficiency. “Barriers to Industrial Energy Efficiency” also pinpoints opportunities to address many of these factors. The report…

    Full Story
  • Process Puzzler: Sort Out a Sewer Snafu

    This Month’s Puzzler We’re having problems with our plant wastewater system (Figure 1). First, we can’t seem to get the nominal flow out of our new fiberglass neutralization system — we constantly back up in the neutralizer. Second, the drains in the plant are backing up. Our plant manager…

    Full Story
  • Consider These Water Best Practices

    By Chemical Processing Staff

    Oil production is water dependent – plain and simple. Biofeedstocks need water for growth and crude oil needs water for drilling, extraction and conversion. Beyond oil, water is a critical utility at all process plants. It serves as both a heating and cooling medium. Another plain and simple…

    Full Story

Latest Products